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Science 6 October 2006:
Vol. 314. no. 5796, pp. 64 - 65
DOI: 10.1126/science.1133757
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Perspectives

CELL SIGNALING:
The Double Life of a Transcription Factor Takes It Outside the Nucleus

Chan Young Park and Richard Dolmetsch

Although transcription factors had been thought to act only in the nucleus, new evidence that they can regulate calcium channels in the cytoplasm represents a mechanism for two-way communication within cells.

The authors are in the Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA. E-mail: ricardo.dolmetsch{at}stanford.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)