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Science 29 September 2006:
Vol. 313. no. 5795, p. 1849
DOI: 10.1126/science.313.5795.1849j
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Figure 1 Exon junction complex (EJC) assembles on newly spliced RNA and is a central effector of messenger RNA functions. Andersen et al. (p. 1968, published online 24 August) have determined a 2.3 angstrom resolution structure of a core EJC complex bound to an RNA oligonucleotide. The EJC core comprises the DEAD-box RNA helicase eIF4AIII bound to an adenosine triphosphate (ATP) analog, and three additional proteins--MLN51, MAGOH, and Y14. Tight binding of the complex to RNA requires that ATP hydrolysis by eIF4AIII is inhibited. The structure shows how eIF4AIII binds sequence-independently to the RNA backbone and how the protein partners participate in RNA recognition and regulate ATP hydrolysis of the DEAD-box helicase.

CREDIT: ANDERSEN ET AL.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)