Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 September 2006:
Vol. 313. no. 5793, pp. 1626 - 1628
DOI: 10.1126/science.1128115
Prev | Table of Contents | Next

Reports

High Gamma Power Is Phase-Locked to Theta Oscillations in Human Neocortex

R. T. Canolty,1* E. Edwards,1,2 S. S. Dalal,3 M. Soltani,1,2 S. S. Nagarajan,3,4 H. E. Kirsch,5 M. S. Berger,6 N. M. Barbaro,5,6 R. T. Knight1,2,3,5,6

We observed robust coupling between the high- and low-frequency bands of ongoing electrical activity in the human brain. In particular, the phase of the low-frequency theta (4 to 8 hertz) rhythm modulates power in the high gamma (80 to 150 hertz) band of the electrocorticogram, with stronger modulation occurring at higher theta amplitudes. Furthermore, different behavioral tasks evoke distinct patterns of theta/high gamma coupling across the cortex. The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans.

1 Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
2 Department of Psychology, University of California, Berkeley, CA 94720, USA.
3 Department of Bioengineering, University of California, San Francisco, CA 94143, USA.
4 Department of Radiology, University of California, San Francisco, CA 94143, USA.
5 Department of Neurology, University of California, San Francisco, CA 94143, USA.
6 Department of Neurosurgery, University of California, San Francisco, CA 94143, USA.

* To whom correspondence should be addressed. E-mail: rcanolty{at}berkeley.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Broadband Shifts in Local Field Potential Power Spectra Are Correlated with Single-Neuron Spiking in Humans.
J. R. Manning, J. Jacobs, I. Fried, and M. J. Kahana (2009)
J. Neurosci. 29, 13613-13620
   Abstract »    Full Text »    PDF »
Theta Oscillations Mediate Interaction between Prefrontal Cortex and Medial Temporal Lobe in Human Memory.
K. L. Anderson, R. Rajagovindan, G. A. Ghacibeh, K. J. Meador, and M. Ding (2009)
Cereb Cortex
   Abstract »    Full Text »    PDF »
The Phase of Ongoing EEG Oscillations Uncovers the Fine Temporal Structure of Conscious Perception.
V. Wyart and C. Sergent (2009)
J. Neurosci. 29, 12839-12841
   Full Text »    PDF »
From the Cover: Learning sculpts the spontaneous activity of the resting human brain.
C. M. Lewis, A. Baldassarre, G. Committeri, G. L. Romani, and M. Corbetta (2009)
PNAS 106, 17558-17563
   Abstract »    Full Text »    PDF »
Gamma-Band Synchronization in the Macaque Hippocampus and Memory Formation.
M. J. Jutras, P. Fries, and E. A. Buffalo (2009)
J. Neurosci. 29, 12521-12531
   Abstract »    Full Text »    PDF »
Intracranial EEG Reveals a Time- and Frequency-Specific Role for the Right Inferior Frontal Gyrus and Primary Motor Cortex in Stopping Initiated Responses.
N. Swann, N. Tandon, R. Canolty, T. M. Ellmore, L. K. McEvoy, S. Dreyer, M. DiSano, and A. R. Aron (2009)
J. Neurosci. 29, 12675-12685
   Abstract »    Full Text »    PDF »
Neuronal correlates of functional magnetic resonance imaging in human temporal cortex.
G. A. Ojemann, D. P. Corina, N. Corrigan, J. Schoenfield-McNeill, A. Poliakov, L. Zamora, and S. Zanos (2009)
Brain
   Abstract »    Full Text »    PDF »
Neural Representations of Individual Stimuli in Humans Revealed by Gamma-Band Electrocorticographic Activity.
J. Jacobs and M. J. Kahana (2009)
J. Neurosci. 29, 10203-10214
   Abstract »    Full Text »    PDF »
A Microsaccadic Rhythm Modulates Gamma-Band Synchronization and Behavior.
C. A. Bosman, T. Womelsdorf, R. Desimone, and P. Fries (2009)
J. Neurosci. 29, 9471-9480
   Abstract »    Full Text »    PDF »
Minding time in an amodal representational space.
V. van Wassenhove (2009)
Phil Trans R Soc B 364, 1815-1830
   Abstract »    Full Text »    PDF »
Hyperdopaminergia and NMDA Receptor Hypofunction Disrupt Neural Phase Signaling.
K. Dzirasa, A. J. Ramsey, D. Y. Takahashi, J. Stapleton, J. M. Potes, J. K. Williams, R. R. Gainetdinov, K. Sameshima, M. G. Caron, and M. A. L. Nicolelis (2009)
J. Neurosci. 29, 8215-8224
   Abstract »    Full Text »    PDF »
The development of neural synchrony reflects late maturation and restructuring of functional networks in humans.
P. J. Uhlhaas, F. Roux, W. Singer, C. Haenschel, R. Sireteanu, and E. Rodriguez (2009)
PNAS 106, 9866-9871
   Abstract »    Full Text »    PDF »
Nuclei Accumbens Phase Synchrony Predicts Decision-Making Reversals Following Negative Feedback.
M. X Cohen, N. Axmacher, D. Lenartz, C. E. Elger, V. Sturm, and T. E. Schlaepfer (2009)
J. Neurosci. 29, 7591-7598
   Abstract »    Full Text »    PDF »
Predictive coding under the free-energy principle.
K. Friston and S. Kiebel (2009)
Phil Trans R Soc B 364, 1211-1221
   Abstract »    Full Text »    PDF »
Correlation Between BOLD fMRI and Theta-Band Local Field Potentials in the Human Hippocampal Area.
A. Ekstrom, N. Suthana, D. Millett, I. Fried, and S. Bookheimer (2009)
J Neurophysiol 101, 2668-2678
   Abstract »    Full Text »    PDF »
Decoupling the Cortical Power Spectrum Reveals Real-Time Representation of Individual Finger Movements in Humans.
K. J. Miller, S. Zanos, E. E. Fetz, M. den Nijs, and J. G. Ojemann (2009)
J. Neurosci. 29, 3132-3137
   Abstract »    Full Text »    PDF »
Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons.
P. Wulff, A. A. Ponomarenko, M. Bartos, T. M. Korotkova, E. C. Fuchs, F. Bahner, M. Both, A. B. L. Tort, N. J. Kopell, W. Wisden, et al. (2009)
PNAS 106, 3561-3566
   Abstract »    Full Text »    PDF »
Nonlinear Phase-Phase Cross-Frequency Coupling Mediates Communication between Distant Sites in Human Neocortex.
F. Darvas, K. J. Miller, R. P. N. Rao, and J. G. Ojemann (2009)
J. Neurosci. 29, 426-435
   Abstract »    Full Text »    PDF »
Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task.
A. B. L. Tort, M. A. Kramer, C. Thorn, D. J. Gibson, Y. Kubota, A. M. Graybiel, and N. J. Kopell (2008)
PNAS 105, 20517-20522
   Abstract »    Full Text »    PDF »
NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex.
S. Middleton, J. Jalics, T. Kispersky, F. E. N. LeBeau, A. K. Roopun, N. J. Kopell, M. A. Whittington, and M. O. Cunningham (2008)
PNAS 105, 18572-18577
   Abstract »    Full Text »    PDF »
Neural Correlates of High-Gamma Oscillations (60-200 Hz) in Macaque Local Field Potentials and Their Potential Implications in Electrocorticography.
S. Ray, N. E. Crone, E. Niebur, P. J. Franaszczuk, and S. S. Hsiao (2008)
J. Neurosci. 28, 11526-11536
   Abstract »    Full Text »    PDF »
Selective, State-Dependent Activation of Somatostatin-Expressing Inhibitory Interneurons in Mouse Neocortex.
E. E. Fanselow, K. A. Richardson, and B. W. Connors (2008)
J Neurophysiol 100, 2640-2652
   Abstract »    Full Text »    PDF »
Hyperventilation-induced hypocapnia changes the pattern of electroencephalographic bicoherence growth during sevoflurane anaesthesia.
K. Hayashi, M. Fujikawa, and T. Sawa (2008)
Br. J. Anaesth. 101, 666-672
   Abstract »    Full Text »    PDF »
Neuronal Mechanisms of Cortical Alpha Oscillations in Awake-Behaving Macaques.
A. Bollimunta, Y. Chen, C. E. Schroeder, and M. Ding (2008)
J. Neurosci. 28, 9976-9988
   Abstract »    Full Text »    PDF »
Origin of Synchronized Low-Frequency Blood Oxygen Level-Dependent Fluctuations in the Primary Visual Cortex.
J.S. Anderson (2008)
AJNR Am. J. Neuroradiol. 29, 1722-1729
   Abstract »    Full Text »    PDF »
Distinct Gamma-Band Components Reflect the Short-Term Memory Maintenance of Different Sound Lateralization Angles.
J. Kaiser, T. Heidegger, M. Wibral, C. F. Altmann, and W. Lutzenberger (2008)
Cereb Cortex 18, 2286-2295
   Abstract »    Full Text »    PDF »
The Role of Oscillations and Synchrony in Cortical Networks and Their Putative Relevance for the Pathophysiology of Schizophrenia.
P. J. Uhlhaas, C. Haenschel, D. Nikolic, and W. Singer (2008)
Schizophr Bull 34, 927-943
   Abstract »    Full Text »    PDF »
Event-Related EEG Time-Frequency Analysis: An Overview of Measures and An Analysis of Early Gamma Band Phase Locking in Schizophrenia.
B. J. Roach and D. H. Mathalon (2008)
Schizophr Bull 34, 907-926
   Abstract »    Full Text »    PDF »
Very Slow EEG Fluctuations Predict the Dynamics of Stimulus Detection and Oscillation Amplitudes in Humans.
S. Monto, S. Palva, J. Voipio, and J. M. Palva (2008)
J. Neurosci. 28, 8268-8272
   Abstract »    Full Text »    PDF »
Two distinct activity patterns of fast-spiking interneurons during neocortical UP states.
M. V. Puig, M. Ushimaru, and Y. Kawaguchi (2008)
PNAS 105, 8428-8433
   Abstract »    Full Text »    PDF »
Revealing Past Memories: Proactive Interference and Ketamine-Induced Memory Deficits.
J. J. Chrobak, J. R. Hinman, and H. R. Sabolek (2008)
J. Neurosci. 28, 4512-4520
   Abstract »    Full Text »    PDF »
Entrainment of Neuronal Oscillations as a Mechanism of Attentional Selection.
P. Lakatos, G. Karmos, A. D. Mehta, I. Ulbert, and C. E. Schroeder (2008)
Science 320, 110-113
   Abstract »    Full Text »    PDF »
A human intracranial study of long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing.
P. Sehatpour, S. Molholm, T. H. Schwartz, J. R. Mahoney, A. D. Mehta, D. C. Javitt, P. K. Stanton, and J. J. Foxe (2008)
PNAS 105, 4399-4404
   Abstract »    Full Text »    PDF »
The Oscillation Score: An Efficient Method for Estimating Oscillation Strength in Neuronal Activity.
R. C. Muresan, O. F. Jurjut, V. V. Moca, W. Singer, and D. Nikolic (2008)
J Neurophysiol 99, 1333-1353
   Abstract »    Full Text »    PDF »
Large-Scale Gamma-Band Phase Synchronization and Selective Attention.
S. M. Doesburg, A. B. Roggeveen, K. Kitajo, and L. M. Ward (2008)
Cereb Cortex 18, 386-396
   Abstract »    Full Text »    PDF »
Genetic Contributions to Long-Range Temporal Correlations in Ongoing Oscillations.
K. Linkenkaer-Hansen, D. J. A. Smit, A. Barkil, T. E. M. van Beijsterveldt, A. B. Brussaard, D. I. Boomsma, A. van Ooyen, and E. J. C. de Geus (2007)
J. Neurosci. 27, 13882-13889
   Abstract »    Full Text »    PDF »
Neural Synchrony in Schizophrenia: From Networks to New Treatments.
J. M. Ford, J. H. Krystal, and D. H. Mathalon (2007)
Schizophr Bull 33, 848-852
   Abstract »    Full Text »    PDF »
The Relation of Brain Oscillations to Attentional Networks.
J. Fan, J. Byrne, M. S. Worden, K. G. Guise, B. D. McCandliss, J. Fossella, and M. I. Posner (2007)
J. Neurosci. 27, 6197-6206
   Abstract »    Full Text »    PDF »
Spike Timing Amplifies the Effect of Electric Fields on Neurons: Implications for Endogenous Field Effects.
T. Radman, Y. Su, J. H. An, L. C. Parra, and M. Bikson (2007)
J. Neurosci. 27, 3030-3036
   Abstract »    Full Text »    PDF »
Response Anticipation and Response Conflict: An Event-Related Potential and Functional Magnetic Resonance Imaging Study.
J. Fan, R. Kolster, J. Ghajar, M. Suh, R. T. Knight, R. Sarkar, and B. D. McCandliss (2007)
J. Neurosci. 27, 2272-2282
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)