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Science 18 August 2006:
Vol. 313. no. 5789, p. 888
DOI: 10.1126/science.313.5789.888j
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The tumor suppressor protein, p53, transcriptionally activates genes that control cell cycle arrest, apoptosis, and other cellular processes that help to prevent tumor development. Teodoro et al. (p. 968) now show that p53 appears to keep tumors in check by activating the gene encoding alpha(II) collagen prolyl-4-hydroxylase. This enzyme is required for the extracellular release of collagen-derived peptides, such as endostatin and tumstatin, that are potent inhibitors of tumor angiogenesis. The p53 gene is inactivated in many human cancers, presumably leading to reduced production of endogenous antiangiogenic peptides that defend against tumor growth.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)