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Science 4 August 2006:
Vol. 313. no. 5787, p. 588
DOI: 10.1126/science.313.5787.588l
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This Week in Science

While investigating the mechanisms that control gene expression during the sexual stages of malaria parasites, Mair et al. (p. 667; see the Perspective by Hajduk) discovered an RNA helicase that binds to and represses a spectrum of parasite messenger RNAs. The helicase is found in cytoplasmic P-granules, ribonucleoprotein complexes containing translationally repressed mRNAs, which are stored ready for activation after fertilization. Parasites that lack the helicase are developmentally defective after gamete fusion. Understanding this key developmental transition in the complex life cycle of the malaria parasite may point to new leads for malaria control.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)