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Science 7 July 2006:
Vol. 313. no. 5783, p. 13
DOI: 10.1126/science.313.5783.13o
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After mitosis, cells must physically separate from one another in a process known as cytokinesis. Failure of cytokinesis can promote tumorigenesis. Yoshida et al. (p. 108, published online 8 June) examined how cell cycle signals are linked to the control of Rho-type GTPases and cytokinesis. Using budding yeast as a model, the authors identified a conserved signaling pathway whereby the mitotic polo kinase controls contractile ring assembly by directly regulating Rho1, the small guanosine triphosphatase that is required for cytokinesis in all eukaryotes.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)