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Science 26 May 2006:
Vol. 312. no. 5777, p. 1101
DOI: 10.1126/science.312.5777.1101p
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This Week in Science
Pituitary adenomas are slow-growing, generally benign, tumors that may occur in as much as 25% of the population. These tumors can pose serious health risks through mechanical compression of adjacent tissue and/or through altered secretion of pituitary-derived hormones, such as growth hormone. Little is known about the molecular mechanisms by which these tumors arise. Taking advantage of genealogy data in Finland dating back to the 1700s, Vierimaa et al. (p. 1228) discovered that many individuals with pituitary adenomas are genetically predisposed to develop these tumors because they carry mutations in the gene encoding the aryl hydrocarbon receptor interacting protein (AIP). These results should facilitate the identification of at-risk individuals as well as stimulate research into the functional role of AIP in the pathogenesis of these tumors.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
