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Science 12 May 2006:
Vol. 312. no. 5775, p. 848
DOI: 10.1126/science.1110994
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Technical Comments

Response to Comment on "Evidence for Positive Epistasis in HIV-1"

Sebastian Bonhoeffer,1* Colombe Chappey,2 Neil T. Parkin,2 Jeannette M. Whitcomb,2 Christos J. Petropoulos2

Wang et al. analyzed artificially biased data to show that our results can be explained by a bias against sequences with low fitness. We explicitly acknowledged this potential caveat in our original study. Showing that an artificially introduced bias can produce a spurious signal of positive epistasis does not demonstrate that such bias exists in our original data.

1 Institute of Integrative Biology, ETH Zurich, ETH Zentrum CHN, CH-8092 Zurich, Switzerland.
2 Monogram BioSciences, Inc., 345 Oyster Point Boulevard, South San Francisco, CA 94080–1913, USA.

* To whom correspondence should be addressed. E-mail: sebastian.bonhoeffer{at}env.ethz.ch

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Science. ISSN 0036-8075 (print), 1095-9203 (online)