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Science 5 May 2006:
Vol. 312. no. 5774, pp. 758 - 762
DOI: 10.1126/science.1125572
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Reports

Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex

Francesca Sargolini,1 Marianne Fyhn,1 Torkel Hafting,1 Bruce L. McNaughton,1,2 Menno P. Witter,1,3 May-Britt Moser,1 Edvard I. Moser1*

Grid cells in the medial entorhinal cortex (MEC) are part of an environment-independent spatial coordinate system. To determine how information about location, direction, and distance is integrated in the grid-cell network, we recorded from each principal cell layer of MEC in rats that explored two-dimensional environments. Whereas layer II was predominated by grid cells, grid cells colocalized with head-direction cells and conjunctive grid x head-direction cells in the deeper layers. All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion–based navigation.

1 Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
2 Arizona Research Laboratories Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA.
3 Research Institute Neurosciences, Department of Anatomy and Neurosciences, Vrije Universiteit University Medical Center, Amsterdam, Netherlands.

* To whom correspondence should be addressed. E-mail: edvard.moser{at}ntnu.no

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