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Science 5 May 2006:
Vol. 312. no. 5774, p. 653
DOI: 10.1126/science.312.5774.653n
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This Week in Science

Secretory and membrane proteins contain so-called signal sequences that are recognized by the signal recognition particle (SRP) as they emerge from the ribosome. The nascent proteins are then targeted to the membrane by docking with the SRP receptor, which facilitates transfer of the ribosome to the translocon and subsequent translocation of the protein across the membrane. Halic et al. (p. 745) used cryo-electron microscopy to generate a structure at approximately 8 angstrom resolution of a docking complex consisting of an SRP-bound 80S ribosome and SRP receptor.




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