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Science Signaling - Call For Papers

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Science 28 April 2006:
Vol. 312. no. 5773, p. 496
DOI: 10.1126/science.312.5773.496k

This Week in Science

Voltage sensor domains comprise four transmembrane segments (S1 to S4) and are responsible for sensing changes in membrane potential and controlling gating of the pore domain (S5 and S6) in voltage-gated ion channels. Sasaki et al. (p. 589, published online 23 March) have identified a protein consisting primarily of a voltage-sensor domain (VSD) that appears to mediate voltage-gated proton currents. The proton currents exhibit pH-dependent gating and are sensitive to zinc ion concentrations, features that are characteristic of voltage-gated proton channels.






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Science. ISSN 0036-8075 (print), 1095-9203 (online)