Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Signaling - Call for Papers

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 April 2006:
Vol. 312. no. 5770, p. 55
DOI: 10.1126/science.1115362
Prev | Table of Contents | Next

Technical Comments

Response to Comment on "PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-{kappa}B Activation"

Ki-young Lee, Jae-Hyuck Shim, Matthew S. Hayden, Jan-Schulze Luehrmann, Sankar Ghosh*

In their comment, Gruber et al. report constitutive phosphorylation of protein kinase C {theta} at threonine residue 538. However, they fail to note that, consistent with our results, a number of other groups have previously reported inducible phosphorylation of Thr-538 in T cells. Although the physiological relevance of this discrepancy is unclear, substantial differences in experimental conditions and reagents may account for the conflicting observations.

Section of Immunology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.

* To whom correspondence should be addressed. E-mail: Sankar.ghosh{at}yale.edu

Read the Full Text

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products