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Science 7 April 2006:
Vol. 312. no. 5770, p. 15
DOI: 10.1126/science.312.5770.15i
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This Week in Science

Figure 1 Early in animal development, the embryo switches from using maternally provided messenger RNA (mRNA) transcripts to expressing mostly zygotic genes. During this maternal-to-zygotic transition, a large number of maternal mRNAs are somehow eliminated. Giraldez et al. (p. 75, published online 16 February; see the Perspective by Cohen and Brennecke) examined possible microRNA (miRNA)-based mechanisms and identified 203 putative targets for the zebrafish miRNA miR-430, which is specifically expressed at the maternal-to-zygotic transition. Hundreds of miR-430 target mRNAs are maternally expressed during early development, and miR-430 can promote their deacetylation and decay. Thus, during the maternal-to-zygotic transition in zebrafish embryogenesis, miR-430 plays a critical role.

CREDIT: ANTONIO J. GIRALDEZ




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