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Science 7 April 2006:
Vol. 312. no. 5770, p. 15
DOI: 10.1126/science.312.5770.15b
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This Week in Science

Carbon-hydrogen bonds in organic molecules and biopolymers are among the least reactive chemical groups, and in chemical synthesis, a C-H bond is first activated by oxygenation or halogenation reactions that can be unselective or difficult to control. Godula and Sames (p. 67) review recent progress in transition metal catalysis that has allowed direct, selective formation of carbon-carbon bonds from isolated C-H bonds. These synthetic routes offer great potential for increased synthetic efficiency in preparing complex molecules such as drug precursors.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)