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The liver can regenerate its volume after major tissue loss.In a mouse model of liver regeneration, thrombocytopenia, orimpaired platelet activity resulted in the failure to initiatecellular proliferation in the liver. Platelets are major carriersof serotonin in the blood. In thrombocytopenic mice, a serotoninagonist reconstituted liver proliferation. The expression of5-HT2A and 2B subtype serotonin receptors in the liver increasedafter hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibitedliver regeneration. Liver regeneration was also blunted in micelacking tryptophan hydroxylase 1, which is the rate-limitingenzyme for the synthesis of peripheral serotonin. This failureof regeneration was rescued by reloading serotonin-free plateletswith a serotonin precursor molecule. These results suggest thatplatelet-derived serotonin is involved in the initiation ofliver regeneration.
1 Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland. 2 Department of Pathology, University Hospital of Zurich, Switzerland. 3 Institut National de la Santé et de la Recherche Médicale 311, Etablissement Français du Sang-Alsace, Strasbourg, France. 4 Max Planck Institute for Molecular Genetics, Berlin, Germany. 5 Max Delbrück Center for Molecular Medicine, Berlin, Germany.
* To whom correspondence should be addressed. E-mail: clavien{at}chir.unizh.ch
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PNAS
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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|Abstract »|Full Text »|PDF »
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Strategies for Safer Liver Surgery and Partial Liver Transplantation.
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Altered expression of a limited number of genes contributes to cardiac decompensation during chronic ventricular tachypacing in dogs.
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Physiol Genomics
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