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Science 24 March 2006:
Vol. 311. no. 5768, pp. 1774 - 1775
DOI: 10.1126/science.1123510
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Reports

Reversal of Diabetes in Non-Obese Diabetic Mice Without Spleen Cell-Derived ß Cell Regeneration

Anita S. Chong,1* Jikun Shen,1 Jing Tao,1 Dengping Yin,1,3 Andrey Kuznetsov,2 Manami Hara,2 Louis H. Philipson2

Autoimmune destruction of ß cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although ß cells in these mice were not derived from donor splenocytes.

1 Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
2 Section of Endocrinology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
3 Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.

* To whom correspondence should be addressed. E-mail: achong{at}uchicago.edu

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Science 314, 1243b
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