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Large-Scale Sequence Analysis of Avian Influenza Isolates
John C. Obenauer,1Jackie Denson,1Perdeep K. Mehta,1Xiaoping Su,1Suraj Mukatira,1David B. Finkelstein,1Xiequn Xu,1Jinhua Wang,1Jing Ma,1Yiping Fan,1Karen M. Rakestraw,1Robert G. Webster,2,4Erich Hoffmann,2Scott Krauss,2Jie Zheng,3Ziwei Zhang,3Clayton W. Naeve1,4*
The spread of H5N1 avian influenza viruses (AIVs) from Chinato Europe has raised global concern about their potential toinfect humans and cause a pandemic. In spite of their substantialthreat to human health, remarkably little AIV whole-genome informationis available. We report here a preliminary analysis of the firstlarge-scale sequencing of AIVs, including 2196 AIV genes and169 complete genomes. We combine this new information with publicAIV data to identify new gene alleles, persistent genotypes,compensatory mutations, and a potential virulence determinant.
1 Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. 2 Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. 3 Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. 4 Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
* To whom correspondence should be addressed. E-mail: clayton.naeve{at}stjude.org
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TECHNICAL COMMENTS
Edward C. Holmes, David J. Lipman, Dmitriy Zamarin, and Jonathan W. Yewdell (15 September 2006) Science313 (5793), 1573b.
[DOI: 10.1126/science.1131729] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
John C. Obenauer, Yiping Fan, and Clayton W. Naeve (15 September 2006) Science313 (5793), 1573c.
[DOI: 10.1126/science.1131840] |Abstract »|Full Text »|PDF »
PERSPECTIVES
Robert M. Krug (17 March 2006) Science311 (5767), 1562.
[DOI: 10.1126/science.1125998] |Summary »|Full Text »|PDF »
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