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Science 17 March 2006:
Vol. 311. no. 5767, pp. 1562 - 1563
DOI: 10.1126/science.1125998
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Perspectives

VIROLOGY:
Clues to the Virulence of H5N1 Viruses in Humans

Robert M. Krug

Why is H5N1 avian influenza so virulent? Genomic analysis of various isolates suggests that, in addition to two known surface proteins, a third previously unnoticed sequence in a small viral protein may contribute to virulence.

The author is at the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. E-mail: rkrug{at}mail.utexas.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans.
C. Korteweg and J. Gu (2008)
Am. J. Pathol. 172, 1155-1170
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Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses.
M. M. Mukhtar, S. T. Rasool, D. Song, C. Zhu, Q. Hao, Y. Zhu, and J. Wu (2007)
J. Gen. Virol. 88, 3094-3099
   Abstract »    Full Text »    PDF »
An RNA conformational shift in recent H5N1 influenza A viruses.
A. P. Gultyaev, H. A. Heus, and R. C. L. Olsthoorn (2007)
Bioinformatics 23, 272-276
   Abstract »    Full Text »    PDF »
Influenza A Virus PB1-F2 Protein Contributes to Viral Pathogenesis in Mice..
D. Zamarin, M. B. Ortigoza, and P. Palese (2006)
J. Virol. 80, 7976-7983
   Abstract »    Full Text »    PDF »


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