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Science 17 March 2006:
Vol. 311. no. 5767, p. 1517
DOI: 10.1126/science.311.5767.1517h
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This Week in Science

Large-scale sequence analysis of avian flu isolates based on 4339 virus genes from many wild birds confirms long-known facts of flu biology, such as the variability of hemagglutinin and neuraminidase sequences, the frequency of reassortment, and the restricted compatibility of internal virion subunits. Obenauer et al. (p. 1576, published online 26 January; see the Perspective by Krug) have developed the means to characterize these viruses by a technique they term "proteotyping" and use the method to identify specific combinations of genes and gene products that travel together. They also identified a previously overlooked motif that appears to correlate closely with virulence, at least in strains of avian origin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)