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Science 10 March 2006:
Vol. 311. no. 5766, p. 1341
DOI: 10.1126/science.311.5766.1341o

This Week in Science

Although there are elegant interaction maps available for yeast and Drosophila, it will become more difficult to find complete, high-quality data for higher organisms. Zhong and Sternberg (p. 1481; see the Perspective by Eddy) have developed a computational approach to cross-species data integration and have used it to generate a map of Caenorhabditis elegans genetic interactions. To test the robustness of their predictions, RNA interference analysis was used to verify novel interactors predicted for let-60 and itr-1.






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Science. ISSN 0036-8075 (print), 1095-9203 (online)