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Science 3 March 2006:
Vol. 311. no. 5765, p. 1209
DOI: 10.1126/science.311.5765.1209h
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In order to understand how evolution occurred, from the development of molecular networks to organ systems and the relationships of organisms, it is necessary to have a framework. Ciccarelli et al. (p. 1283) used genomic information to construct a tree that can be easily automated and updated. They started with 36 genes universally present in 191 species for which orthologs could be unambiguously identified. An important component was a procedure for identifying and removing apparent lateral gene transfer effects. Using this open-source resource, the authors confirmed phylogenetic relationships and put forward hypotheses about the ancestor to modern bacteria.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)