Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 24 February 2006: Vol. 311. no. 5764, pp. 1160 - 1164 DOI: 10.1126/science.1122545
|
|
Reports
Dendritic Cell Apoptosis in the Maintenance of Immune Tolerance
Min Chen,1*
Yui-Hsi Wang,2
Yihong Wang,2
Li Huang,1
Hector Sandoval,1
Yong-Jun Liu,2
Jin Wang1*
Apoptosis in the immune system is critical for maintaining self-tolerance and preventing autoimmunity. Nevertheless, inhibiting apoptosis in lymphocytes is not alone sufficient to break self-tolerance, suggesting the involvement of other cell types. We investigated whether apoptosis in dendritic cells (DCs) helps regulate self-tolerance by generating transgenic mice expressing the baculoviral caspase inhibitor, p35, in DCs (DC-p35). DC-p35 mice displayed defective DC apoptosis, resulting in their accumulation and, in turn, chronic lymphocyte activation and systemic autoimmune manifestations. The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance.
1 Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
2 Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
* To whom correspondence should be addressed. E-mail: jinwang{at}bcm.edu (J.W.); minc{at}bcm.edu (M.C.)
Read the Full Text
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.
- Y. Sawatani, T. Miyamoto, S. Nagai, M. Maruya, J. Imai, K. Miyamoto, N. Fujita, K. Ninomiya, T. Suzuki, R. Iwasaki, et al. (2008)
Int. Immunol.
| Abstract »
| Full Text »
| PDF »
- B Lymphocyte Stimulator Regulates Adaptive Immune Responses by Directly Promoting Dendritic Cell Maturation.
- S. K. Chang, S. A. Mihalcik, and D. F. Jelinek (2008)
J. Immunol.
180, 7394-7403
| Abstract »
| Full Text »
| PDF »
- Enhanced Dendritic Cell Survival Attenuates Lipopolysaccharide-Induced Immunosuppression and Increases Resistance to Lethal Endotoxic Shock.
- E. L. Gautier, T. Huby, F. Saint-Charles, B. Ouzilleau, M. J. Chapman, and P. Lesnik (2008)
J. Immunol.
180, 6941-6946
| Abstract »
| Full Text »
| PDF »
- Rheumatoid Arthritis Synovium Contains Two Subsets of CD83-DC-LAMP- Dendritic Cells with Distinct Cytokine Profiles.
- M. C. Lebre, S. L. Jongbloed, S. W. Tas, T. J.M. Smeets, I. B. McInnes, and P. P. Tak (2008)
Am. J. Pathol.
172, 940-950
| Abstract »
| Full Text »
| PDF »
- Increasing the Survival of Dendritic Cells In Vivo Does Not Replace the Requirement for CD4+ T Cell Help during Primary CD8+ T Cell Responses.
- K. E. Matthews, J. S. Qin, J. Yang, I. F. Hermans, M. J. Palmowski, V. Cerundolo, and F. Ronchese (2007)
J. Immunol.
179, 5738-5747
| Abstract »
| Full Text »
| PDF »
- Autoimmunity Stimulated by Adoptively Transferred Dendritic Cells Is Initiated by Both {alpha}beta and {gamma}{delta} T Cells but Does Not Require MyD88 Signaling.
- D. A. Martin, K. Zhang, J. Kenkel, G. Hughes, E. Clark, A. Davidson, and K. B. Elkon (2007)
J. Immunol.
179, 5819-5828
| Abstract »
| Full Text »
| PDF »
- Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.
- R. Obst, H.-M. van Santen, R. Melamed, A. O. Kamphorst, C. Benoist, and D. Mathis (2007)
PNAS
104, 15460-15465
| Abstract »
| Full Text »
| PDF »
- Antigen Transmission by Replicating Antigen-Bearing Dendritic Cells.
- J. Diao, E. Winter, W. Chen, F. Xu, and M. S. Cattral (2007)
J. Immunol.
179, 2713-2721
| Abstract »
| Full Text »
| PDF »
- Transfusion of Apoptotic {beta}-Cells Induces Immune Tolerance to {beta}-Cell Antigens and Prevents Type 1 Diabetes in NOD Mice.
- C.-Q. Xia, R. Peng, Y. Qiu, M. Annamalai, D. Gordon, and M. J. Clare-Salzler (2007)
Diabetes
56, 2116-2123
| Abstract »
| Full Text »
| PDF »
- {beta}1-Adrenergic Receptor Autoantibodies Mediate Dilated Cardiomyopathy by Agonistically Inducing Cardiomyocyte Apoptosis.
- D. Jane-wit, C. Z. Altuntas, J. M. Johnson, S. Yong, P. J. Wickley, P. Clark, Q. Wang, Z. B. Popovic, M. S. Penn, D. S. Damron, et al. (2007)
Circulation
116, 399-410
| Abstract »
| Full Text »
| PDF »
- Histone Deacetylase Inhibitors Affect Dendritic Cell Differentiation and Immunogenicity.
- A. Nencioni, J. Beck, D. Werth, F. Grunebach, F. Patrone, A. Ballestrero, and P. Brossart (2007)
Clin. Cancer Res.
13, 3933-3941
| Abstract »
| Full Text »
| PDF »
- Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance.
- T. Izawa, N. Ishimaru, K. Moriyama, M. Kohashi, R. Arakaki, and Y. Hayashi (2007)
Blood
110, 242-250
| Abstract »
| Full Text »
| PDF »
- B7-2 Regulates Survival, Phenotype, and Function of APCs.
- D. Yadav and N. Sarvetnick (2007)
J. Immunol.
178, 6236-6241
| Abstract »
| Full Text »
| PDF »
- Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity.
- M. Chen, L. Huang, and J. Wang (2007)
Blood
109, 4360-4367
| Abstract »
| Full Text »
| PDF »
- Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.
- U. A. Hasan, C. Caux, I. Perrot, A.-C. Doffin, C. Menetrier-Caux, G. Trinchieri, M. Tommasino, and J. Vlach (2007)
PNAS
104, 8047-8052
| Abstract »
| Full Text »
| PDF »
- Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell.
- G. T. Belz, L. Zhang, M. D. H. Lay, F. Kupresanin, and M. P. Davenport (2007)
PNAS
104, 6341-6346
| Abstract »
| Full Text »
| PDF »
- Progesterone inhibits mature rat dendritic cells in a receptor-mediated fashion.
- C. L. Butts, S. A. Shukair, K. M. Duncan, E. Bowers, C. Horn, E. Belyavskaya, L. Tonelli, and E. M. Sternberg (2007)
Int. Immunol.
19, 287-296
| Abstract »
| Full Text »
| PDF »
- IL-6 Produced by Dendritic Cells from Lupus-Prone Mice Inhibits CD4+CD25+ T Cell Regulatory Functions.
- S. Wan, C. Xia, and L. Morel (2007)
J. Immunol.
178, 271-279
| Abstract »
| Full Text »
| PDF »
- Transgenic Expression of the Viral FLIP MC159 Causes lpr/gld-Like Lymphoproliferation and Autoimmunity.
- M. Woelfel, J. Bixby, M. A. Brehm, and F. K.-M. Chan (2006)
J. Immunol.
177, 3814-3820
| Abstract »
| Full Text »
| PDF »
|
|