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Science 24 February 2006:
Vol. 311. no. 5764, pp. 1146 - 1149
DOI: 10.1126/science.1120519
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Reports

Cell Type Regulates Selective Segregation of Mouse Chromosome 7 DNA Strands in Mitosis

Athanasios Armakolas and Amar J. S. Klar*

After chromosome replication, sister chromatid copies are generally thought to segregate randomly to daughter cells. However, sister chromatids differ in their DNA strands, with each chromatid inheriting one older strand that is paired to a newly synthesized strand. Genetic analysis with a homologous chromosome pair indicated nonrandom chromatid distribution in embryonic stem cells. Biased segregation pattern was also found in all 100 endoderm cells examined, but not in any of the 165 neuroectoderm cells. In contrast, the mesoderm, cardiomyocyte, and pancreatic cells exhibited a random mode of segregation. Strand distribution mechanisms regulated by cell type may have consequences for cellular differentiation and for evolving strategies for developmental mechanisms.

Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702–1201, USA.

* To whom correspondence should be addressed. E-mail: klar{at}ncifcrf.gov

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of Putative Bovine Mammary Epithelial Stem Cells by Their Retention of Labeled DNA Strands.
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Experimental Biology and Medicine 232, 1381-1390
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A Hypothesis for How Chromosome 11 Translocations Cause Psychiatric Disorders.
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Genetics 177, 1259-1262
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Hydrogen symbioses in evolution and disease.
A.C. Williams and D.B. Ramsden (2007)
QJM 100, 451-459
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Left-Right Dynein Motor Implicated in Selective Chromatid Segregation in Mouse Cells.
A. Armakolas and A. J. S. Klar (2007)
Science 315, 100-101
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Comment on "Cell Type Regulates Selective Segregation of Mouse Chromosome 7 DNA Strands in Mitosis".
J. E. Haber (2006)
Science 313, 1045b
   Abstract »    Full Text »    PDF »
Response to Comment on "Cell Type Regulates Selective Segregation of Mouse Chromosome 7 DNA Strands in Mitosis".
A. J. S. Klar and A. Armakolas (2006)
Science 313, 1045c
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)