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Science 24 February 2006:
Vol. 311. no. 5764, p. 1068
DOI: 10.1126/science.311.5764.1068j
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This Week in Science

Damage to DNA in cells (like that produced by some anticancer drugs) is sensed by the cell and causes cellular responses that determine whether a cell lives or dies. Wu et al. (p. 1141; see the Perspective by Bartek and Jiri) provide a new link by which this signal can be conveyed from the nucleus to the cytoplasm. The protein kinase ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates NEMO, one of the proteins in the IkappaB kinase (IKK) complex that regulates the activity of the transcription factor NF-kappaB. NF-kappaB in turn mediates signals that promote cell survival. After DNA damage, ATM was exported from the nucleus and then interacted in the cytoplasm with another protein in the IKK complex, ELKS. Activated IKK then caused activation of NF-kappaB-dependent transcription.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)