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Science 17 February 2006:
Vol. 311. no. 5763, p. 913
DOI: 10.1126/science.311.5763.913l
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Although norepinephrine is generally accepted to play a role in the adverse effects of opiate withdrawal, its role in mediating the rewarding and stimulatory effects of opiates remains controversial.Olson et al. (p. 1017) discovered that genetically engineered mice unable to synthesize norepinephrine, due to a targeted disruption of the dopamine beta-hydroxylase (DBH) gene, appear totally blind to morphine reward, as measured in a conditioned place preference test. Importantly, sensitivity to morphine reward was completely rescued by restoration of DBH expression in a specific set of neurons.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)