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Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans
Samuel R. Chamberlain,1,3*Ulrich Müller,1,2,3Andrew D. Blackwell,1,3Luke Clark,2,3Trevor W. Robbins,2,3Barbara J. Sahakian1,3
Cognitive functions dependent on the prefrontal cortex, suchas the ability to suppress behavior (response inhibition) andto learn from complex feedback (probabilistic learning), playcritical roles in activities of daily life. To what extent dodifferent neurochemical systems modulate these two cognitivefunctions? Here, using stop-signal and probabilistic learningtasks, we show a double dissociation for the involvement ofnoradrenaline and serotonin in human cognition. In healthy volunteers,inhibition of central noradrenaline reuptake improved responseinhibition but had no effect on probabilistic learning, whereasinhibition of central serotonin reuptake impaired probabilisticlearning with no effect on response inhibition.
1 Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Box 189, Cambridge CB2 2QQ, UK. 2 Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK. 3 Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
* To whom correspondence should be addressed. E-mail: src33{at}cam.ac.uk
Orbitofrontal Dysfunction in Patients with Obsessive-Compulsive Disorder and Their Unaffected Relatives.
S. R. Chamberlain, L. Menzies, A. Hampshire, J. Suckling, N. A. Fineberg, N. del Campo, M. Aitken, K. Craig, A. M. Owen, E. T. Bullmore, et al. (2008)
Science
321, 421-422
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Low-Serotonin Levels Increase Delayed Reward Discounting in Humans.
N. Schweighofer, M. Bertin, K. Shishida, Y. Okamoto, S. C. Tanaka, S. Yamawaki, and K. Doya (2008)
J. Neurosci.
28, 4528-4532
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The Orbital Prefrontal Cortex and Drug Addiction in Laboratory Animals and Humans.
B. J. EVERITT, D. M. HUTCHESON, K. D. ERSCHE, Y. PELLOUX, J. W. DALLEY, and T. W. ROBBINS (2007)
Ann. N.Y. Acad. Sci.
1121, 576-597
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Converging Evidence for a Fronto-Basal-Ganglia Network for Inhibitory Control of Action and Cognition.
A. R. Aron, S. Durston, D. M. Eagle, G. D. Logan, C. M. Stinear, and V. Stuphorn (2007)
J. Neurosci.
27, 11860-11864
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Atomoxetine increases salivary cortisol in healthy volunteers.
S. R. Chamberlain, U. Muller, S. Cleary, T. W. Robbins, and B. J. Sahakian (2007)
J Psychopharmacol
21, 545-549
|Abstract »|PDF »
Lifting the Veil on Trichotillomania.
S. R. Chamberlain, L. Menzies, B. J. Sahakian, and N. A. Fineberg (2007)
Am J Psychiatry
164, 568-574
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Lack of deleterious effects of buspirone on cognition in healthy male volunteers.
S. R. Chamberlain, U. Muller, J. B. Deakin, P. R. Corlett, J. Dowson, R. N. Cardinal, M. R. F. Aitken, T. W. Robbins, and B. J. Sahakian (2007)
J Psychopharmacol
21, 210-215
|Abstract »|PDF »
Impaired Cognitive Flexibility and Motor Inhibition in Unaffected First-Degree Relatives of Patients With Obsessive-Compulsive Disorder.
S. R. Chamberlain, N. A. Fineberg, L. A. Menzies, A. D. Blackwell, E. T. Bullmore, T. W. Robbins, and B. J. Sahakian (2007)
Am J Psychiatry
164, 335-338
|Abstract »|Full Text »|PDF »
Promoting Resilience in Children and Youth: Preventive Interventions and Their Interface with Neuroscience.
