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Science 27 January 2006:
Vol. 311. no. 5760, p. 432
DOI: 10.1126/science.311.5760.432l
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The postsynaptic density (PSD) is a large and dynamic protein complex on the postsynaptic side of neural synapses that helps communicate incoming signals to cytoplasmic targets. Shank proteins are located deep in the PSD and may be involved in organizing the structure of the complex. Baron et al. (p. 531) have determined the structure of the sterile alpha motif domain of a Shank protein and show that it forms large sheets composed of helical fibers stacked side-by-side. Sheets of the Shank protein may form a platform for the construction of the PSD complex.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)