Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Vanessa M. D'Costa,1Katherine M. McGrann,1Donald W. Hughes,2Gerard D. Wright1*
Microbial resistance to antibiotics currently spans all knownclasses of natural and synthetic compounds. It has not onlyhindered our treatment of infections but also dramatically reshapeddrug discovery, yet its origins have not been systematicallystudied. Soil-dwelling bacteria produce and encounter a myriadof antibiotics, evolving corresponding sensing and evading strategies.They are a reservoir of resistance determinants that can bemobilized into the microbial community. Study of this reservoircould provide an early warning system for future clinicallyrelevant antibiotic resistance mechanisms.
1 Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada, L8N 3Z5. 2 Department of Chemistry, McMaster University, Ontario, Canada, L8N 3Z5.
* To whom correspondence should be addressed. E-mail: wrightge{at}mcmaster.ca
The editors suggest the following Related Resources on Science sites:
In Science Magazine
PERSPECTIVES
Alexander Tomasz (20 January 2006) Science311 (5759), 342.
[DOI: 10.1126/science.1123982] |Summary »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two Distinct Major Facilitator Superfamily Drug Efflux Pumps Mediate Chloramphenicol Resistance in Streptomyces coelicolor.
J. J. Vecchione, B. Alexander Jr., and J. K. Sello (2009)
Antimicrob. Agents Chemother.
53, 4673-4677
|Abstract »|Full Text »|PDF »
A Novel Tryptophanyl-tRNA Synthetase Gene Confers High-Level Resistance to Indolmycin.
J. J. Vecchione and J. K. Sello (2009)
Antimicrob. Agents Chemother.
53, 3972-3980
|Abstract »|Full Text »|PDF »
Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics.
M. Savic, J. Lovric, T. I. Tomic, B. Vasiljevic, and G. L. Conn (2009)
Nucleic Acids Res.
37, 5420-5431
|Abstract »|Full Text »|PDF »
Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora.
M. O. A. Sommer, G. Dantas, and G. M. Church (2009)
Science
325, 1128-1131
|Abstract »|Full Text »|PDF »
Mutational paths towards increased fluoroquinolone resistance in Legionella pneumophila.
I. Almahmoud, E. Kay, D. Schneider, and M. Maurin (2009)
J. Antimicrob. Chemother.
64, 284-293
|Abstract »|Full Text »|PDF »
The role of natural environments in the evolution of resistance traits in pathogenic bacteria.
Noncanonical Vancomycin Resistance Cluster from Desulfitobacterium hafniense Y51.
L. Kalan, S. Ebert, T. Kelly, and G. D. Wright (2009)
Antimicrob. Agents Chemother.
53, 2841-2845
|Abstract »|Full Text »|PDF »
Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste.
J. C. Chee-Sanford, R. I. Mackie, S. Koike, I. G. Krapac, Y.-F. Lin, A. C. Yannarell, S. Maxwell, and R. I. Aminov (2009)
J. Environ. Qual.
38, 1086-1108
|Abstract »|Full Text »|PDF »
Genetic Analysis of Factors Affecting Susceptibility of Bacillus subtilis to Daptomycin.
A.-B. Hachmann, E. R. Angert, and J. D. Helmann (2009)
Antimicrob. Agents Chemother.
53, 1598-1609
|Abstract »|Full Text »|PDF »
Metagenomic Screening for Bleomycin Resistance Genes.
T. Mori, S. Mizuta, H. Suenaga, and K. Miyazaki (2008)
Appl. Envir. Microbiol.
74, 6803-6805
|Abstract »|Full Text »|PDF »
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5.
W. F. Fricke, M. S. Wright, A. H. Lindell, D. M. Harkins, C. Baker-Austin, J. Ravel, and R. Stepanauskas (2008)
J. Bacteriol.
190, 6779-6794
|Abstract »|Full Text »|PDF »
Characterization of an Inducible, Antibiotic-Resistant Aminoacyl-tRNA Synthetase Gene in Streptomyces coelicolor.
G. Dantas, M. O. A. Sommer, R. D. Oluwasegun, and G. M. Church (2008)
Science
320, 100-103
|Abstract »|Full Text »|PDF »
Antibiotic-resistant soil bacteria in transgenic plant fields.
S. Demaneche, H. Sanguin, J. Pote, E. Navarro, D. Bernillon, P. Mavingui, W. Wildi, T. M. Vogel, and P. Simonet (2008)
PNAS
105, 3957-3962
|Abstract »|Full Text »|PDF »
Mechanisms of Resistance to Daptomycin in Enterococcus faecium.
C. I. Montero, F. Stock, and P. R. Murray (2008)
Antimicrob. Agents Chemother.
52, 1167-1170
|Abstract »|Full Text »|PDF »
Temporal Dynamics and Impact of Manure Storage on Antibiotic Resistance Patterns and Population Structure of Escherichia coli Isolates from a Commercial Swine Farm.
G. Yim, H. Huimi Wang, and J. Davies FRS (2007)
Phil Trans R Soc B
362, 1195-1200
|Abstract »|Full Text »|PDF »
Diversity of antibiotic resistance integrative and conjugative elements among haemophili.
I. D. Dimopoulou, S. I. Kartali, R. M. Harding, T. E. A. Peto, and D. W. Crook (2007)
J. Med. Microbiol.
56, 838-846
|Abstract »|Full Text »|PDF »
Novel Links between Antibiotic Resistance and Antibiotic Production.
J. R. Nodwell (2007)
J. Bacteriol.
189, 3683-3685
|Full Text »|PDF »
Antimycobacterial activity of bacteriocins and their complexes with liposomes.
V. Sosunov, V. Mischenko, B. Eruslanov, E. Svetoch, Y. Shakina, N. Stern, K. Majorov, G. Sorokoumova, A. Selishcheva, and A. Apt (2007)
J. Antimicrob. Chemother.
59, 919-925
|Abstract »|Full Text »|PDF »
Telithromycin-Nonsusceptible Clinical Isolates of Streptococcus pneumoniae from Europe.
A. Al-Lahham, P. C. Appelbaum, M. van der Linden, and R. R. Reinert (2006)
Antimicrob. Agents Chemother.
50, 3897-3900
|Abstract »|Full Text »|PDF »
Dirty Tales of Antibiotic Resistance.
(2006)
Journal Watch Infectious Diseases
2006, 5
|Full Text »
