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Science 13 January 2006:
Vol. 311. no. 5758, pp. 187 - 188
DOI: 10.1126/science.1123221
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Perspectives

SYSTEMS BIOLOGY:
When Proteomes Collide

Joel S. Bader and John Chant

Although the protein interaction network of herpesvirus does not resemble that of its human host, it merges at multiple points with the human network during infection. Such a strategy may optimize conditions for establishing a pathogenic state.

J. S. Bader is in the Department of Biomedical Engineering and High-Throughput Biology Center, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21215, USA. E-mail: joel.bader{at}jhu.edu J. Chant is at Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. E-mail: jchant{at}gene.com

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Precision and recall estimates for two-hybrid screens.
H. Huang and J. S. Bader (2009)
Bioinformatics 25, 372-378
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Science. ISSN 0036-8075 (print), 1095-9203 (online)