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Originally published in Science Express on 1 December 2005
Science 6 January 2006:
Vol. 311. no. 5757, pp. 83 - 87
DOI: 10.1126/science.1117729
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Reports

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

Darin K. Fogg,1* Claire Sibon,1* Chaouki Miled,1 Steffen Jung,2 Pierre Aucouturier,3 Dan R. Littman,4 Ana Cumano,5,6 Frederic Geissmann1,7{dagger}

Macrophages and dendritic cells (DCs) are crucial for immune and inflammatory responses and belong to a network of cells that has been termed the mononuclear phagocyte system (MPS). However, the origin and lineage of these cells remain poorly understood. Here, we describe the isolation and clonal analysis of a mouse bone marrow progenitor that is specific for monocytes, several macrophage subsets, and resident spleen DCs in vivo. It was also possible to recapitulate this differentiation in vitro by using treatment with the cytokines macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS.

1 INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades Institute, 75015 Paris, France.
2 Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
3 INSERM U712, 75012 Paris, France.
4 Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
5 INSERM U668, 75015 Paris, France.
6 Institut Pasteur, Lymphocyte Development Unit, 75015 Paris, France.
7 Pathology Department, Necker Enfants Malades Hospital, University of Paris–Descartes Faculty of Medicine and Assistance Publique Hopitaux de Paris, 75015 Paris, France.

* These authors contributed equally to this study.

{dagger} To whom correspondence should be addressed. E-mail: geissman{at}necker.fr

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