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Science 23 December 2005:
Vol. 310. no. 5756, p. 1865
DOI: 10.1126/science.310.5756.1865m
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This Week in Science

Principal inflammatory responses in mammals include the induction of nitric oxide and prostaglandin synthesis in cells of the immune system. Kim et al. (p. 1966) report that the enzymes that produce these molecules, nitric oxide synthase and cyclooxygenase-2, respectively, interact in macrophage cells. Nitric oxide synthase delivers NO to cyclooxygenase-2. This modification of cyclooxygenase-2 by nitric oxide, known as S-nitrosylation, activates the enzyme. This synergism between the two systems may help in the design of potential novel anti-inflammatory drugs.




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