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Science 9 December 2005:
Vol. 310. no. 5754, p. 1581
DOI: 10.1126/science.310.5754.1581m
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The complex mechanics of the eukaryotic cell cycle is monitored at a number of points to ensure that everything is going according to plan, before the next step in the process is executed. Known checkpoints include DNA replication, DNA damage, and spindle function. Bhalla and Dernburg (p. 1683) identify a checkpoint that monitors synapsis, or pairing between homologous chromosomes during the meiotic (haploid gamete-producing) cell cycle in Caenorhabditis elegans, which ensures the accurate chromosome segregation during division. The checkpoint requires chromosomal sites known as pairing centers, where synapsis initiates, and is distinct from the DNA damage checkpoint monitoring meiotic recombination. The checkpoint involves the PCH2 gene, which is also involved in the pachytene checkpoint in budding yeast.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)