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Science 9 December 2005:
Vol. 310. no. 5754, p. 1581
DOI: 10.1126/science.310.5754.1581a
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This Week in Science

Figure 1 One strategy for building molecular nanostructures in three dimensions is to exploit the connectivity afforded by nucleic acid structures. In many cases, the steps needed to select particular base pairing to create structures such as cubes lead to long, multistep syntheses. Goodman et al. (p. 1661) have developed a rapid self-assembly process that creates DNA tetrahedra that have 10 to 30 base pairs on each edge. Four single strands that contain the complementary sequences for six edges anneal in seconds in 95% yield, and single diastereomeric products are formed. The authors also present atomic force microscopy studies of the compression of a single DNA tetrahedron.

CREDIT: GOODMAN ET AL.




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