Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 November 2005:
Vol. 310. no. 5751, pp. 1135 - 1138
DOI: 10.1126/science.1106587
Prev | Table of Contents | Next

Review

Exploring and Engineering the Cell Surface Interface

Molly M. Stevens* and Julian H. George

Cells are inherently sensitive to local mesoscale, microscale, and nanoscale patterns of chemistry and topography. We review current approaches to control cell behavior through the nanoscale engineering of materials surfaces. Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration.

Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK.

* To whom correspondence should be addressed. E-mail: m.stevens{at}imperial.ac.uk

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Heparinized Micropatterned Surfaces for the Spatial Control of Human Mesenchymal Stem Cells.
Jin Woo Bae, J. H. Choi, Tae Eun Kim, Ki Dong Park, Ji Youn Kim, Yong Doo Park, and K. Sun (2009)
Journal of Bioactive and Compatible Polymers 24, 493-506
   Abstract »    PDF »
Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration.
Z. Zheng, Y. Wei, G. Wang, Y. Gong, and X. Zhang (2009)
J Biomater Appl 24, 209-229
   Abstract »    PDF »
Review Paper: A Review of the Cellular Response on Electrospun Nanofibers for Tissue Engineering.
D.R. Nisbet, J.S. Forsythe, W. Shen, D.I. Finkelstein, and M.K. Horne (2009)
J Biomater Appl 24, 7-29
   Abstract »    PDF »
Flexible electrical recording from cells using nanowire transistor arrays.
T. Cohen-Karni, B. P. Timko, L. E. Weiss, and C. M. Lieber (2009)
PNAS 106, 7309-7313
   Abstract »    Full Text »    PDF »
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties.
A. M. Kloxin, A. M. Kasko, C. N. Salinas, and K. S. Anseth (2009)
Science 324, 59-63
   Abstract »    Full Text »    PDF »
Stem cell bioprocessing: fundamentals and principles.
M. R Placzek, I-M. Chung, H. M Macedo, S. Ismail, T. Mortera Blanco, M. Lim, J. Min Cha, I. Fauzi, Y. Kang, D. C.L Yeo, et al. (2009)
J R Soc Interface 6, 209-232
   Abstract »    Full Text »    PDF »
Long-term viability of coronary artery smooth muscle cells on poly(L-lactide-co-{epsilon}-caprolactone) nanofibrous scaffold indicates its potential for blood vessel tissue engineering.
Y. Dong, T. Yong, S. Liao, C. K Chan, and S Ramakrishna (2008)
J R Soc Interface 5, 1109-1118
   Abstract »    Full Text »    PDF »
Electrospun Nanoporous Fiber.
Yue Wu, J.-Y. Yu, and Chi Ma (2008)
Textile Research Journal 78, 812-815
   Abstract »    PDF »
Colloidal lithography and current fabrication techniques producing in-plane nanotopography for biological applications.
M.A Wood (2007)
J R Soc Interface 4, 1-17
   Abstract »    Full Text »    PDF »
Differences in Chlamydia trachomatis Serovar E Growth Rate in Polarized Endometrial and Endocervical Epithelial Cells Grown in Three-Dimensional Culture.
N. V. Guseva, S. Dessus-Babus, C. G. Moore, J. D. Whittimore, and P. B. Wyrick (2007)
Infect. Immun. 75, 553-564
   Abstract »    Full Text »    PDF »
Polypyrrole-based conducting polymers and interactions with biological tissues.
D.D Ateh, H.A Navsaria, and P Vadgama (2006)
J R Soc Interface 3, 741-752
   Abstract »    Full Text »    PDF »
Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells.
V. Gupta and K. J. Grande-Allen (2006)
Cardiovasc Res 72, 375-383
   Abstract »    Full Text »    PDF »
Cell-directed assembly of lipid-silica nanostructures providing extended cell viability..
H. K. Baca, C. Ashley, E. Carnes, D. Lopez, J. Flemming, D. Dunphy, S. Singh, Z. Chen, N. Liu, H. Fan, et al. (2006)
Science 313, 337-341
   Abstract »    Full Text »    PDF »
Tissue Cells Feel and Respond to the Stiffness of Their Substrate.
D. E. Discher, P. Janmey, and Y.-l. Wang (2005)
Science 310, 1139-1143
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)