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Science 18 November 2005:
Vol. 310. no. 5751, p. 1085
DOI: 10.1126/science.310.5751.1085k
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Figure 1 The immune synapse forms at the interface between a T cell and an antigen-presenting cell (APC) and is composed of discrete domains of stimulatory molecules and receptors critical for T cell activation. Mossman et al. (p. 1191) have imposed physical constraints on the synapse domains using a hybrid junction between a live cell and an anchored lipid bilayer (representing the APC surface). The authors directly tested the effects of membrane reorganization on the signals delivered by the synapse. Constraint of T-cell receptor ligand pairs to the periphery--rather than the center of the synapse where they normally coalesce--sustained (rather than diminished) synapse signaling, establishing a relation between the duration of T-cell receptor signals and their position in the synapse.

CREDIT: MOSSMAN ET AL.




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