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Originally published in Science Express on 1 September 2005
Science 21 October 2005:
Vol. 310. no. 5747, pp. 486 - 489
DOI: 10.1126/science.1115791
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Reports

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

Muriel Brengues,* Daniela Teixeira,* Roy Parker{dagger}

Eukaryotic cells contain nontranslating messenger RNA concentrated in P-bodies, which are sites where the mRNA can be decapped and degraded. We present evidence that mRNA molecules within yeast P-bodies can also return to translation. First, inhibiting delivery of new mRNAs to P-bodies leads to their disassembly independent of mRNA decay. Second, P-bodies decline in a translation initiation–dependent manner during stress recovery. Third, reporter mRNAs concentrate in P-bodies when translation initiation is blocked and resume translation and exit P-bodies when translation is restored. Fourth, stationary phase yeast have large P-bodies containing mRNAs that reenter translation when growth resumes. The reciprocal movement of mRNAs between polysomes and P-bodies is likely to be important in the control of mRNA translation and degradation. Moreover, the presence of related proteins in P-bodies and maternal mRNA storage granules suggests this mechanism is widely adapted for mRNA storage.

Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721–0106, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: rrparker{at}u.arizona.edu

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