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Science 14 October 2005:
Vol. 310. no. 5746, pp. 321 - 324
DOI: 10.1126/science.1117196
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Reports

A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome

Simon Myers, Leonardo Bottolo, Colin Freeman, Gil McVean,* Peter Donnelly*{dagger}

Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.

Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.

* These authors jointly directed the project.

{dagger} To whom correspondence should be addressed. E-mail: donnelly{at}stats.ox.ac.uk

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