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Science 16 September 2005:
Vol. 309. no. 5742, p. 1785
DOI: 10.1126/science.309.5742.1785m
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Calorie restriction can extend the life span of certain organisms, including mammals, and can even increase the replicative life span of yeast. However, it has not been clear whether or not the effect in yeast is entirely dependent on Sir2, a histone deacetylase of the sirtuin family. Sir2 is thought to reduce genome instability by suppressing recombination of ribosomal RNA. Lamming et al. (p. 1861, published online 28 July 2005) have identified another SIR2-related gene in yeast called homolog of SIR2 (HST2) that also mediates the calorie restriction signal, even in the absence of Sir2. Thus, a Sir2-independent mechanism of life-span extension by calorie restriction involves another member of the sirtuin family.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)