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Science 2 September 2005:
Vol. 309. no. 5740, p. 1453
DOI: 10.1126/science.309.5740.1453k
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This Week in Science

Examination of genomes is revealing high levels of noncoding transcription and there is currently much focus on these molecular mechanisms and the function of their transcript products. Kobayashi and Ganley (p. 1581) now elucidate function of bidirectional transcription of an intergenic region of ribosomal DNA (rDNA) repeats, termed E-pro. Noncoding transcription dissociates cohesion from the rDNA intergenic region and allows unequal recombination with a resulting change in rDNA copy number. This work explains how transcription can regulate rDNA amplification.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)