Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 July 2005:
Vol. 309. no. 5734, pp. 619 - 623
DOI: 10.1126/science.1114037
Prev | Table of Contents | Next

Reports

Independent Codes for Spatial and Episodic Memory in Hippocampal Neuronal Ensembles

Stefan Leutgeb,1 Jill K. Leutgeb,1 Carol A. Barnes,1,2 Edvard I. Moser,1 Bruce L. McNaughton,1,2* May-Britt Moser1

Hippocampal neurons were recorded under conditions in which the recording chamber was varied but its location remained unchanged versus conditions in which an identical chamber was encountered in different places. Two forms of neuronal pattern separation occurred. In the variable cue-constant place condition, the firing rates of active cells varied, often over more than an order of magnitude, whereas the location of firing remained constant. In the variable place-constant cue condition, both location and rates changed, so that population vectors for a given location in the chamber were statistically independent. These independent encoding schemes may enable simultaneous representation of spatial and episodic memory information.

1 Centre for the Biology of Memory, Medical-Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
2 Arizona Research Laboratories Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA.

* To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation.
C. D. Clelland, M. Choi, C. Romberg, G. D. Clemenson Jr., A. Fragniere, P. Tyers, S. Jessberger, L. M. Saksida, R. A. Barker, F. H. Gage, et al. (2009)
Science 325, 210-213
   Abstract »    Full Text »    PDF »
Motivational states activate distinct hippocampal representations to guide goal-directed behaviors.
P. J. Kennedy and M. L. Shapiro (2009)
PNAS 106, 10805-10810
   Abstract »    Full Text »    PDF »
Visual object pattern separation deficits in nondemented older adults.
C. K. Toner, E. Pirogovsky, C. B. Kirwan, and P. E. Gilbert (2009)
Learn. Mem. 16, 338-342
   Abstract »    Full Text »    PDF »
Representation of Geometric Borders in the Entorhinal Cortex.
T. Solstad, C. N. Boccara, E. Kropff, M.-B. Moser, and E. I. Moser (2008)
Science 322, 1865-1868
   Abstract »    Full Text »    PDF »
Dopamine D1 Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty.
A. H. Tran, T. Uwano, T. Kimura, E. Hori, M. Katsuki, H. Nishijo, and T. Ono (2008)
J. Neurosci. 28, 13390-13400
   Abstract »    Full Text »    PDF »
Hippocampal Network Dynamics Constrain the Time Lag between Pyramidal Cells across Modified Environments.
K. Diba and G. Buzsaki (2008)
J. Neurosci. 28, 13448-13456
   Abstract »    Full Text »    PDF »
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations.
T. Klausberger and P. Somogyi (2008)
Science 321, 53-57
   Abstract »    Full Text »    PDF »
Synaptic Commitment: Developmentally Regulated Reciprocal Changes in Hippocampal Granule Cell NMDA and AMPA Receptors Over the Lifespan.
Z. Yang, M. Krause, G. Rao, B. L. McNaughton, and C. A. Barnes (2008)
J Neurophysiol 99, 2760-2768
   Abstract »    Full Text »    PDF »
Firing Rate Dynamics in the Hippocampus Induced by Trajectory Learning.
D. Ji and M. A. Wilson (2008)
J. Neurosci. 28, 4679-4689
   Abstract »    Full Text »    PDF »
Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear.
J. Ji and S. Maren (2008)
Learn. Mem. 15, 244-251
   Abstract »    Full Text »    PDF »
Qualitatively Different Hippocampal Subfield Engagement Emerges with Mastery of a Spatial Memory Task by Rats.
G. L. Poirier, E. Amin, and J. P. Aggleton (2008)
J. Neurosci. 28, 1034-1045
   Abstract »    Full Text »    PDF »
The CA3 network as a memory store for spatial representations.
G. Papp, M. P Witter, and A. Treves (2007)
Learn. Mem. 14, 732-744
   Abstract »    Full Text »    PDF »
Pattern separation, pattern completion, and new neuronal codes within a continuous CA3 map.
S. Leutgeb and J. K. Leutgeb (2007)
Learn. Mem. 14, 745-757
   Abstract »    Full Text »    PDF »
Using immediate-early genes to map hippocampal subregional functions.
S. Kubik, T. Miyashita, and J. F. Guzowski (2007)
Learn. Mem. 14, 758-770
   Abstract »    Full Text »    PDF »
Stress-induced alterations in hippocampal plasticity, place cells, and spatial memory.
J. J. Kim, H. J. Lee, A. C. Welday, E. Song, J. Cho, P. E. Sharp, M. W. Jung, and H. T. Blair (2007)
PNAS 104, 18297-18302
   Abstract »    Full Text »    PDF »
Overcoming interference: An fMRI investigation of pattern separation in the medial temporal lobe.
C. B. Kirwan and C. E.L. Stark (2007)
Learn. Mem. 14, 625-633
   Abstract »    Full Text »    PDF »
Hippocampal CA1 Place Cells Encode Intended Destination on a Maze with Multiple Choice Points.
J. A. Ainge, M. Tamosiunaite, F. Woergoetter, and P. A. Dudchenko (2007)
J. Neurosci. 27, 9769-9779
   Abstract »    Full Text »    PDF »
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network.
T. J. McHugh, M. W. Jones, J. J. Quinn, N. Balthasar, R. Coppari, J. K. Elmquist, B. B. Lowell, M. S. Fanselow, M. A. Wilson, and S. Tonegawa (2007)
Science 317, 94-99
   Abstract »    Full Text »    PDF »
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus.
J. K. Leutgeb, S. Leutgeb, M.-B. Moser, and E. I. Moser (2007)
Science 315, 961-966
   Abstract »    Full Text »    PDF »
Hippocampal Sharp Waves and Reactivation during Awake States Depend on Repeated Sequential Experience.
J. C. Jackson, A. Johnson, and A. D. Redish (2006)
J. Neurosci. 26, 12415-12426
   Abstract »    Full Text »    PDF »
Neural representations of location outside the hippocampus.
J. J. Knierim (2006)
Learn. Mem. 13, 405-415
   Abstract »    Full Text »    PDF »
Transformations of Visuospatial Images.
J. M. Zacks and P. Michelon (2005)
Behav Cogn Neurosci Rev 4, 96-118
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)