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Science 15 July 2005:
Vol. 309. no. 5733, pp. 392 - 393
DOI: 10.1126/science.1114852
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Perspectives
NEUROSCIENCE:
Brain Under Surveillance: The Microglia Patrol
Luc Fetler and Sebastian Amigorena
The environment that cells encounter within tissues is extremely complex and virtually impossible to reconstitute in vitro. Two-photon microscopy on tissues of living animals is rapidly revealing the behavior of cells in their natural environment. In their Perspective, Fetler and Amigorena discuss two recent papers that use this powerful imaging technique to observe the dynamic behavior of microglial cells in a live mouse brain before and after brain injury.
The authors are at the Curie Institute, 26 rue d'Ulm, 75245 Paris Cedex 05, France. L. Fetler is in the Laboratoire Physico-Chimie Curie, CNRS UMR 168, Institut Curie, Paris, France. E-mail: luc.fetler{at}curie.fr S. Amigorena is in the Immunité et Cancer, INSERM U365, Institut Curie, Paris, France. E-mail: sebastian.amigorena{at}curie.fr
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