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Science 15 July 2005:
Vol. 309. no. 5733, pp. 392 - 393
DOI: 10.1126/science.1114852

Perspectives

NEUROSCIENCE:
Brain Under Surveillance: The Microglia Patrol

Luc Fetler and Sebastian Amigorena

The environment that cells encounter within tissues is extremely complex and virtually impossible to reconstitute in vitro. Two-photon microscopy on tissues of living animals is rapidly revealing the behavior of cells in their natural environment. In their Perspective, Fetler and Amigorena discuss two recent papers that use this powerful imaging technique to observe the dynamic behavior of microglial cells in a live mouse brain before and after brain injury.


The authors are at the Curie Institute, 26 rue d'Ulm, 75245 Paris Cedex 05, France. L. Fetler is in the Laboratoire Physico-Chimie Curie, CNRS UMR 168, Institut Curie, Paris, France. E-mail: luc.fetler{at}curie.fr S. Amigorena is in the Immunité et Cancer, INSERM U365, Institut Curie, Paris, France. E-mail: sebastian.amigorena{at}curie.fr

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diabetic Retinopathy: Seeing Beyond Glucose-Induced Microvascular Disease.
D. A. Antonetti, A. J. Barber, S. K. Bronson, W. M. Freeman, T. W. Gardner, L. S. Jefferson, M. Kester, S. R. Kimball, J. K. Krady, K. F. LaNoue, et al. (2006)
Diabetes 55, 2401-2411
   Abstract »    Full Text »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)