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Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes
Malcolm J. Gardner,1*Richard Bishop,2Trushar Shah,2Etienne P. de Villiers,2Jane M. Carlton,1Neil Hall,1Qinghu Ren,1Ian T. Paulsen,1Arnab Pain,3Matthew Berriman,3Robert J. M. Wilson,4Shigeharu Sato,4Stuart A. Ralph,5David J. Mann,6Zikai Xiong,3Shamira J. Shallom,1Janice Weidman,1Lingxia Jiang,1Jeffery Lynn,1Bruce Weaver,1Azadeh Shoaibi,1Alexander R. Domingo,1Delia Wasawo,2Jonathan Crabtree,1Jennifer R. Wortman,1Brian Haas,1Samuel V. Angiuoli,1Todd H. Creasy,1Charles Lu,1Bernard Suh,1Joana C. Silva,1Teresa R. Utterback,1Tamara V. Feldblyum,1Mihaela Pertea,1Jonathan Allen,1William C. Nierman,1Evans L. N. Taracha,2Steven L. Salzberg,1Owen R. White,1Henry A. Fitzhugh,2Subhash Morzaria,2||J. Craig Venter,7Claire M. Fraser,1Vishvanath Nene1
We report the genome sequence of Theileria parva, an apicomplexanpathogen causing economic losses to smallholder farmers in Africa.The parasite chromosomes exhibit limited conservation of genesynteny with Plasmodium falciparum, and its plastid-like genomerepresents the first example where all apicoplast genes areencoded on one DNA strand. We tentatively identify proteinsthat facilitate parasite segregation during host cell cytokinesisand contribute to persistent infection of transformed host cells.Several biosynthetic pathways are incomplete or absent, suggestingsubstantial metabolic dependence on the host cell. One proteinfamily that may generate parasite antigenic diversity is nottelomere-associated.
1 Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA. 2 International Livestock Research Institute, Post Office Box 30709, Nairobi, Kenya. 3 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. 4 National Institute for Medical Research, Ridgeway, Mill Hill, London NW7 1AA, UK. 5 Institut Pasteur, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France. 6 Department of Biological Sciences, Imperial College, London SW7 2AZ, UK. 7 Venter Institute, 9708 Medical Center Drive, Rockville, MD, 20850, USA.
Present address: Lewis Thomas Lab, Department of Molecular Biology,Princeton University, Princeton, NJ 08544, USA.
Present address: Baskin School of Engineering, University ofCalifornia, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064,USA.
Present address: 3709 Summercrest, Ft. Worth, TX 76109, USA.
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REPORTS
Arnab Pain, Hubert Renauld, Matthew Berriman, Lee Murphy, Corin A. Yeats, William Weir, Arnaud Kerhornou, Martin Aslett, Richard Bishop, Christiane Bouchier, Madeleine Cochet, Richard M. R. Coulson, Ann Cronin, Etienne P. de Villiers, Audrey Fraser, Nigel Fosker, Malcolm Gardner, Arlette Goble, Sam Griffiths-Jones, David E. Harris, Frank Katzer, Natasha Larke, Angela Lord, Pascal Maser, Sue McKellar, Paul Mooney, Fraser Morton, Vishvanath Nene, Susan O'Neil, Claire Price, Michael A. Quail, Ester Rabbinowitsch, Neil D. Rawlings, Simon Rutter, David Saunders, Kathy Seeger, Trushar Shah, Robert Squares, Steven Squares, Adrian Tivey, Alan R. Walker, John Woodward, Dirk A. E. Dobbelaere, Gordon Langsley, Marie-Adele Rajandream, Declan McKeever, Brian Shiels, Andrew Tait, Bart Barrell, and Neil Hall (1 July 2005) Science309 (5731), 131.
[DOI: 10.1126/science.1110418] |Abstract »|Full Text »|PDF »|Supporting Online Material »
PERSPECTIVES
David S. Roos (1 July 2005) Science309 (5731), 72.
[DOI: 10.1126/science.1115252] |Summary »|Full Text »|PDF »
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Present address: Lewis Thomas Lab, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. 
Present address: Baskin School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA. 
Present address: 3709 Summercrest, Ft. Worth, TX 76109, USA. 
