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Science 3 June 2005:
Vol. 308. no. 5727, pp. 1424 - 1428
DOI: 10.1126/science.1108595
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Review

Allosteric Mechanisms of Signal Transduction

Jean-Pierre Changeux1* and Stuart J. Edelstein1,2

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.

1 Receptors and Cognition, Institut Pasteur, 75724 Paris Cedex 15, France.
2 Department of Biochemistry, University of Geneva, CH-1211 Geneva 4, Switzerland.

* To whom correspondence should be addressed. E-mail: changeux{at}pasteur.fr

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