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Science 3 June 2005:
Vol. 308. no. 5727, p. 1373
DOI: 10.1126/science.308.5727.1373p
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This Week in Science

Interleukin-2 (IL-2) is central to the immune response. It forms a complex with three cell surface receptors, IL-2R, IL-2R, and IL-2R, to form a complex that signals through activation of downstream tyrosine kinases, JAK3 and STAT. Rickert et al. (p. 1477) have determined a 2.8 angstrom crystal structure of a complex between IL-2 and IL-2R. The IL-2R structure lacks a classical cytokine receptor fold, and the docking mode with IL-2 is distinct from known cytokine recognition modes. The structure provides a framework for engineering of improved IL-2 therapeutics.




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