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Science 3 June 2005:
Vol. 308. no. 5727, p. 1373
DOI: 10.1126/science.308.5727.1373o
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This Week in Science

Kinesin and dynein move organelles along microtubule tracks in the cell. Kinesin carries cargo to the cell periphery, and dynein brings cargo to the interior. Kural et al. (p. 1469, published online 7 April 2005) tracked the movement of peroxisomes labeled with green fluorescent protein inside a live cell at a resolution of 1.5 nanometers in space and 1 millisecond in time. Both kinesin and dynein exhibit 8-nm step sizes in vivo. The two motors do not operate simultaneously on a single peroxisome, but it appears that multiple kinesins or dyneins can work cooperatively to give speeds up to 10 times greater than those observed in vitro.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)