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Science 20 May 2005:
Vol. 308. no. 5725, p. 1084
DOI: 10.1126/science.308.5725.1084j
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The ribosome uses kinetic proofreading and induced-fit mechanisms to ensure the fidelity of the translation reaction. Cochella and Green (p. 1178; see the Perspective by Daviter et al.) analyzed a mutant transfer RNA (tRNA) molecule that promotes mis-incorporation of amino acids. It appears that the tRNA molecule in itself can transmit structural information from the codon:anticodon decoding center to other regions of the ribosome that promote guanosine triphosphate hydrolysis and accommodation of the tRNA in the ribosome acceptor site. Thus, tRNA is more than a passive player in the translation reaction.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)