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Science 22 April 2005:
Vol. 308. no. 5721, p. 518
DOI: 10.1126/science.1108581
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H2S Induces a Suspended Animation–Like State in Mice

Eric Blackstone,1,2 Mike Morrison,2 Mark B. Roth2*

Mammals normally maintain their core body temperature (CBT) despite changes in environmental temperature. Exceptions to this norm include suspended animation–like states such as hibernation, torpor, and estivation. These states are all characterized by marked decreases in metabolic rate, followed by a loss of homeothermic control in which the animal's CBT approaches that of the environment. We report that hydrogen sulfide can induce a suspended animation-like state in a nonhibernating species, the house mouse (Mus musculus). This state is readily reversible and does not appear to harm the animal. This suggests the possibility of inducing suspended animation-like states for medical applications.

1 Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
2 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98105, USA.

* To whom correspondence should be addressed. E-mail: mroth{at}fhcrc.org

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E-Letters:

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Hydrogen sulfide is also highly toxic
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Science Online, 24 May 2005 [Full text]
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Science Online, 24 May 2005 [Full text]
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