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GENETICS: Was the Human Genome Project Worth the Effort?
Stephen P. Daiger
The Human Genome Project is much more than the genetic map of our species. It is also a powerful set of integrated tools for solving problems in medicine and biology. Application of these tools to a common cause of human blindness, age-related macular degeneration, implicates a common variant in the gene encoding complement factor H as a major contributor to the risk of developing this disease (Klein et al., Haines et al., Edwards et al.). The new findings raise hopes for better diagnosis and treatment of macular degeneration and further validate the importance of the Human Genome Project
The author is at the Human Genetics Center, the University of Texas Health Sciences Center, Houston, TX 77030, USA. E-mail: stephen.p.daiger{at}uth.tmc.edu
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In Science Magazine
RESEARCH ARTICLES
Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen-Yue Tsai, Richard S. Sackler, Chad Haynes, Alice K. Henning, John Paul SanGiovanni, Shrikant M. Mane, Susan T. Mayne, Michael B. Bracken, Frederick L. Ferris, Jurg Ott, Colin Barnstable, and Josephine Hoh (15 April 2005) Science308 (5720), 385.
[DOI: 10.1126/science.1109557] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Albert O. Edwards, Robert Ritter, III, Kenneth J. Abel, Alisa Manning, Carolien Panhuysen, and Lindsay A. Farrer (15 April 2005) Science308 (5720), 421.
[DOI: 10.1126/science.1110189] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Jonathan L. Haines, Michael A. Hauser, Silke Schmidt, William K. Scott, Lana M. Olson, Paul Gallins, Kylee L. Spencer, Shu Ying Kwan, Maher Noureddine, John R. Gilbert, Nathalie Schnetz-Boutaud, Anita Agarwal, Eric A. Postel, and Margaret A. Pericak-Vance (15 April 2005) Science308 (5720), 419.
[DOI: 10.1126/science.1110359] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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