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SIGNAL TRANSDUCTION: A New Mediator for an Old Hormone?
Sylvia Curtis Hewitt, Bonnie J. Deroo, Kenneth S. Korach
It is well established that estrogen mediates many of its physiological actions by binding to estrogen receptors in the nucleus, which then activate the transcription of target genes. However, as Hewitt, Deroo and Korach discuss in their Perspective, new work reveals that some of estrogen's effects may be mediated by a nonclassical pathway in which estrogen binds to non-estrogen receptor membrane proteins such as GPR30 (Revankar et al.).
The authors are at the Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. E-mail: korach{at}niehs.nih.gov
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In Science Magazine
REPORTS
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A G Protein-Coupled Receptor For Estrogen: The End Of The Search?.
