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Luís Jaime Mota,Laure Journet,Isabel Sorg,Céline Agrain,Guy R. Cornelis*
Many pathogenic bacteria use a type III secretion nanomachine(an injectisome) to deliver virulence proteins into the cytosolof their eukaryotic host cells. Most injectisomes possess astiff needlelike structure of a genetically defined length.We found that a minimal needle length was required for efficientfunctioning of the Yersinia enterocolitica injectisome. Thisminimal needle length correlated with the length of the majoradhesin at the bacterial surface. The needle may be requiredfor triggering type III secretion, and its length may have evolvedto match specific structures at the bacterial and host cellsurfaces.
Biozentrum, Universität Basel, 4056 Basel, Switzerland.
* To whom correspondence should be addressed. E-mail: guy.cornelis{at}unibas.ch
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